Abstract
Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy Adenophora axilliflora leaves. Its structure was determined by a combination of its spectral data and single-crystal X-ray diffraction analysis, with its absolute configuration elucidated by Marfey's method. Chaetominine was more cytotoxic than 5-fluorouracil against the human leukemia K562 and colon cancer SW1116 cell lines. [structure: see text]
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology*
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Antimetabolites, Antineoplastic / pharmacology
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Campanulaceae / microbiology
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Cell Line, Tumor
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Chaetomium / chemistry*
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Circular Dichroism
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Colonic Neoplasms / drug therapy
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Colonic Neoplasms / pathology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Fluorouracil / pharmacology
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Humans
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology*
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K562 Cells
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Magnetic Resonance Spectroscopy
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Plant Leaves / microbiology
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Spectrometry, Mass, Electrospray Ionization
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Tetrazolium Salts
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Thiazoles
Substances
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Antibiotics, Antineoplastic
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Antimetabolites, Antineoplastic
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Indole Alkaloids
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Tetrazolium Salts
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Thiazoles
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chaetominine
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thiazolyl blue
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Fluorouracil