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Neurology. 2006 Nov 28;67(10):1876-9.

Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register.

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  • 1Department of Neurology, Royal Group of Hospitals, Grosvenor Road, Belfast, BT12 6BA, UK.


It is not known whether the antiepileptic drug (AED) levetiracetam can be used safely in human pregnancy. As part of a study to determine the risks of major congenital malformations (MCMs) for infants exposed to AEDs in utero, we identified all cases exposed to levetiracetam. Three of 117 exposed pregnancies had an MCM (2.7%; 95% CI 0.9% to 7.7%); all 3 were exposed to other AEDs.

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