Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

Pingping Tang; Fatemah Mamdani; Xiaoyi Hu; Jun O Liu; Biao Yu

doi:10.1016/j.bmcl.2006.11.032

Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

Bioorg Med Chem Lett. 2007 Feb 15;17(4):1003-7. doi: 10.1016/j.bmcl.2006.11.032. Epub 2006 Nov 15.

Authors

Pingping Tang¹, Fatemah Mamdani, Xiaoyi Hu, Jun O Liu, Biao Yu

Affiliation

¹ State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

PMID: 17127060
DOI: 10.1016/j.bmcl.2006.11.032

Abstract

Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-alpha-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC(50)=0.078microM) comparable to that of the disaccharide derivative (1).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / pharmacology*
Carbohydrates / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Cholestenones / chemical synthesis*
Cholestenones / pharmacology*
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Indicators and Reagents
Jurkat Cells
Ornithogalum / chemistry*
Saponins / chemical synthesis*
Saponins / pharmacology*
Thymidine / metabolism

Substances

Antineoplastic Agents, Phytogenic
Carbohydrates
Cholestenones
Indicators and Reagents
Saponins
OSW 1
Thymidine