Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 1991 Jul 12;66(1):51-63.

Staufen, a gene required to localize maternal RNAs in the Drosophila egg.

Author information

  • 1Max Planck Institut für Entwicklungsbiologie Abteilung III/Genetik, Tübingen, Federal Republic of Germany.


The posterior group gene staufen is required both for the localization of maternal determinants to the posterior pole of the Drosophila egg and for bicoid RNA to localize correctly to the anterior pole. We report the cloning and sequencing of staufen and show that staufen protein is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with oskar RNA. Once localized, staufen is found in the polar granules and is required to hold other polar granule components at the posterior pole. By the time the egg is laid, staufen protein is also concentrated at the anterior pole, in the same region as bicoid RNA.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk