Mech Ageing Dev. 2007 Jan;128(1):58-63. Epub 2006 Nov 28.

Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.

van de Ven M, Andressoo JO, Holcomb VB, Hasty P, Suh Y, van Steeg H, Garinis GA, Hoeijmakers JH, Mitchell JR.

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Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, P.O. Box 1738, Erasmus MC, 3000DR Rotterdam, The Netherlands.

Abstract

Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

PMID:: 17126380; [PubMed - indexed for MEDLINE]
PMCID:: PMC1919472

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