Int Arch Allergy Immunol. 2007;142(4):265-73. Epub 2006 Nov 22.

Role of cytokines in allergic airway inflammation.

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Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan. nakajimh@faculty.chiba-u.jp

Abstract

Asthma is characterized by intense infiltration of eosinophils and CD4+ T cells into the submucosal tissue of airways. Accumulating evidence indicates that T helper type 2 cell-derived cytokines such as interleukin (IL)-4, IL-5 and IL-13 play critical roles in orchestrating and amplifying allergic inflammation in asthma. In addition, it has been suggested that newly identified cytokines including thymic stromal lymphopoietin, IL-25 and IL-33 are involved in the induction of allergic inflammation in asthma. In this review, we discuss the role of individual cytokines in the pathogenesis of asthma.

PMID:: 17124428; [PubMed - indexed for MEDLINE]

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