Science. 2006 Nov 24;314(5803):1243; author reply 1243.

Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.

Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E.

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Massachusetts General Hospital, Charlestown, MA 02129, USA. faustman@helix.mgh.harvard.edu

Abstract

Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery.

Comment on

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. [Science. 2006]
Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH. Science. 2006 Mar 24; 311(5768):1774-5.
Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. [Science. 2006]
Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue ER. Science. 2006 Mar 24; 311(5768):1778-80.
Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. [Science. 2006]
Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Science. 2006 Mar 24; 311(5768):1775-8.

PMID:: 17124308; [PubMed - indexed for MEDLINE]

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Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. [Science. 2006]
Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution.
Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Science. 2006 Mar 24; 311(5768):1775-8.
Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. [Science. 2006]
Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.
Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue ER. Science. 2006 Mar 24; 311(5768):1778-80.
Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. [Science. 2006]
Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH. Science. 2006 Mar 24; 311(5768):1774-5.
Review Participation of adult bone marrow-derived stem cells in pancreatic regeneration: neogenesis versus endogenesis. [Curr Stem Cell Res Ther. 2007]
Review Participation of adult bone marrow-derived stem cells in pancreatic regeneration: neogenesis versus endogenesis.
Iskovich S, Kaminitz A, Yafe MP, Mizrahi K, Stein J, Yaniv I, Askenasy N. Curr Stem Cell Res Ther. 2007 Dec; 2(4):272-9.
Review Role for oxidative stress in the regeneration of islet beta cells? [J Investig Med. 2004]
Review Role for oxidative stress in the regeneration of islet beta cells?
Haskins K, Kench J, Powers K, Bradley B, Pugazhenthi S, Reusch J, McDuffie M. J Investig Med. 2004 Jan; 52(1):45-9.

See reviews... See all...

Cited by 3 PubMed Central articles

Remission of type 1 diabetes after anti-CD3 antibody treatment and transplantation of embryonic pancreatic precursors. [Endocrinology. 2009]
Remission of type 1 diabetes after anti-CD3 antibody treatment and transplantation of embryonic pancreatic precursors.
Begum S, Chen W, Herold KC, Papaioannou VE. Endocrinology. 2009 Oct; 150(10):4512-20. Epub 2009 Jul 9.
Review Cellular therapies for type 1 diabetes. [Horm Metab Res. 2008]
Review Cellular therapies for type 1 diabetes.
Lee DD, Grossman E, Chong AS. Horm Metab Res. 2008 Feb; 40(2):147-54.
Reversal of Sjogren's-like syndrome in non-obese diabetic mice. [Ann Rheum Dis. 2007]
Reversal of Sjogren's-like syndrome in non-obese diabetic mice.
Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E. Ann Rheum Dis. 2007 Jun; 66(6):812-4. Epub 2006 Dec 19.

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