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Bioorg Med Chem Lett. 2007 Feb 1;17(3):640-4. Epub 2006 Nov 6.

Synthesis of pyochelin-norfloxacin conjugates.

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  • 1Métaux et Microorganismes: Chimie, Biologie et Applications, UMR 7175-LC1 Institut Gilbert Laustriat CNRS-Université Louis Pasteur (Strasbourg I), ESBS, Boulevard Sébastien Brant, F-67400 Illkirch, France.


Using synthetic functionalized analogues of pyochelin, a siderophore common to several pathogenic Pseudomonas and Burkholderia species, four fluoroquinolone-pyochelin conjugates were efficiently synthesized and evaluated for their biological activities.

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