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    Matrix Biol. 2007 Mar;26(2):140-3. Epub 2006 Oct 20.

    The consequence of PRELP overexpression on skin.

    Grover J, Lee ER, Mounkes LC, Stewart CL, Roughley PJ.

    Source

    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada.

    Abstract

    PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in which the human PRELP transgene was placed under control of the CMV promoter. A connective tissue phenotype was observed in the skin, where the organization of collagen fibrils in the dermis was perturbed and the thickness of the hypodermal fat layer was diminished.

    PMID:
    17123807
    [PubMed - indexed for MEDLINE]

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