Sao Paulo Med J. 2006 May 4;124(3):168-75.

Parkinson's disease and dopamine transporter neuroimaging: a critical review.

Shih MC, Hoexter MQ, Andrade LA, Bressan RA.

Source

Laboratório Interdisciplinar de Neuroimagem e Cognição, Universidade Federal de São Paulo, Rua Dr. Bacelar 334, CEP 04026-001 São Paulo, Brazil. mingchi@psuquiatria.epm.br

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson's disease diagnosis (sensitivity and specificity).

PMID:: 17119698; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Scientific Electronic Library Online

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Icon for Scientific Electronic Library Online

Save items

Related citations in PubMed

Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? [Mov Disord. 2003]
Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it?
Pirker W. Mov Disord. 2003 Oct; 18 Suppl 7:S43-51.
[Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil]. [Arq Neuropsiquiatr. 2006]
[Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil].
Shih MC, Amaro E Jr, Ferraz HB, Hoexter MQ, Goulart FO, Wagner J, Lin LF, Fu YK, Mari JJ, de Lacerda AL, et al. Arq Neuropsiquiatr. 2006 Sep; 64(3A):628-34.
Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease. [Mov Disord. 2003]
Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease.
Lynch DR, Mozley PD, Sokol S, Maas NM, Balcer LJ, Siderowf AD. Mov Disord. 2003 Jul; 18(7):804-12.
Review Disease-related and drug-induced changes in dopamine transporter expression might undermine the reliability of imaging studies of disease progression in Parkinson's disease. [Parkinsonism Relat Disord. 2005]
Review Disease-related and drug-induced changes in dopamine transporter expression might undermine the reliability of imaging studies of disease progression in Parkinson's disease.
Winogrodzka A, Booij J, Wolters ECh. Parkinsonism Relat Disord. 2005 Dec; 11(8):475-84. Epub 2005 Oct 27.
Review SPECT imaging of the dopaminergic system in (premotor) Parkinson's disease. [Parkinsonism Relat Disord. 2007]
Review SPECT imaging of the dopaminergic system in (premotor) Parkinson's disease.
Booij J, Knol RJ. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S425-8.

See reviews... See all...

Cited by 1 PubMed Central article

Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter. [J Labelled Comp Radiopharm. 2009]
Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter.
De Bruyne S, Boos TL, Wyffels L, Goeman JL, Rice KC, De Vos F. J Labelled Comp Radiopharm. 2009 May 28; 52(8):304-311.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Parkinson's disease and dopamine transporter neuroimaging: a critical review.
Parkinson's disease and dopamine transporter neuroimaging: a critical review.
Sao Paulo Med J. 2006 May 4 ;124(3):168-75.

PubMed
When is drug therapy warranted to prevent sudden cardiac death?
When is drug therapy warranted to prevent sudden cardiac death?
Drugs. 1991 ;41 Suppl 2:24-46.

PubMed
2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with...
2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with a broad therapeutic window.
Neuropsychopharmacology. 2007 Jun ;32(6):1302-11. Epub 2006 Nov 22 .

PubMed
Aluminum and other metals in Alzheimer's disease: a review of potential therapy ...
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.
J Alzheimers Dis. 2006 Nov ;10(2-3):331-41.

PubMed
Aluminum and Alzheimer's disease: a new look.
Aluminum and Alzheimer's disease: a new look.
J Alzheimers Dis. 2006 Nov ;10(2-3):179-201.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: