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Physiology (Bethesda). 2006 Dec;21:380-7.

Altered cardiac myocyte Ca regulation in heart failure.

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  • 1Department of Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA.


Ca is critical in both the electrical and mechanical properties of cardiac myocytes, and much is known about ionic currents and the normal excitation-contraction coupling process. In heart failure, there are significant alterations in how myocyte Ca is regulated, and these alterations are critical in dictating both contractile dysfunction and certain cardiac arrhythmias that are characteristic of heart failure.

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