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Br J Cancer. 2006 Dec 18;95(12):1611-25. Epub 2006 Nov 21.

First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours.

Author information

  • 1Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp/University Hospital Antwerp, Edegem 2650, Belgium.

Abstract

The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. However, current methodology of lymphangiogenesis quantification is still characterised by high intra- and interobserver variability. For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. With this consensus report, we therefore would like to initiate discussion on the standardisation of the immunohistochemical method for lymphangiogenesis assessment.

PMID:
17117184
[PubMed - indexed for MEDLINE]
PMCID:
PMC2360768
Free PMC Article

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