Nat Rev Neurosci. 2006 Dec;7(12):911-20.

The neuronal microRNA system.

Source

Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA. kosik@lifesci.ucsb.edu

Abstract

A class of small, non-coding transcripts called microRNAs (miRNAs) that provide a crucial and pervasive layer of post-transcriptional gene regulation has recently emerged and become the focus of intense research. miRNAs are abundant in the nervous system, where they have key roles in development and are likely to be important mediators of plasticity. A highly conserved pathway of miRNA biogenesis is closely linked to the transport and translatability of mRNAs in neurons. Although there are nearly 500 known human miRNA sequences, each of only approximately 21 nucleotides, which bind to multiple mRNA targets, the accurate prediction of miRNA targets seems to lie just beyond our grasp. Nevertheless, the identification of such targets promises to provide new insights into many facets of neuronal function.

PMID:: 17115073; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review MicroRNA signatures in neurological disorders. [Can J Neurol Sci. 2010]
Review MicroRNA signatures in neurological disorders.
Shafi G, Aliya N, Munshi A. Can J Neurol Sci. 2010 Mar; 37(2):177-85.
Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation. [BMC Genomics. 2009]
Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation.
Manakov SA, Grant SG, Enright AJ. BMC Genomics. 2009 Sep 8; 10:419. Epub 2009 Sep 8.
Review MicroRNAs and their regulatory roles in animals and plants. [J Cell Physiol. 2007]
Review MicroRNAs and their regulatory roles in animals and plants.
Zhang B, Wang Q, Pan X. J Cell Physiol. 2007 Feb; 210(2):279-89.
Review MicroRNA function in neuronal development, plasticity and disease. [Biochim Biophys Acta. 2008]
Review MicroRNA function in neuronal development, plasticity and disease.
Fiore R, Siegel G, Schratt G. Biochim Biophys Acta. 2008 Aug; 1779(8):471-8. Epub 2008 Jan 14.
MicroRNA expression profile in murine central nervous system development. [J Mol Neurosci. 2008]
MicroRNA expression profile in murine central nervous system development.
Dogini DB, Ribeiro PA, Rocha C, Pereira TC, Lopes-Cendes I. J Mol Neurosci. 2008 Jul; 35(3):331-7. Epub 2008 May 2.

See reviews... See all...

Cited by 77 PubMed Central articles

Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? [Front Physiol. 2012]
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?
Bellingham SA, Guo BB, Coleman BM, Hill AF. Front Physiol. 2012; 3:124. Epub 2012 May 3.
Fine-Tuning Oligodendrocyte Development by microRNAs. [Front Neurosci. 2012]
Fine-Tuning Oligodendrocyte Development by microRNAs.
Barca-Mayo O, Lu QR. Front Neurosci. 2012; 6:13. Epub 2012 Feb 6.
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. [Proc Natl Acad Sci U S A. 2012]
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, et al. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3125-30. Epub 2012 Feb 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The neuronal microRNA system.
The neuronal microRNA system.
Nat Rev Neurosci. 2006 Dec ;7(12):911-20.

PubMed
Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and ...
Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
Nat Med. 2006 Dec ;12(12):1390-6. Epub 2006 Nov 19 .

PubMed
Dynorphin A activates bradykinin receptors to maintain neuropathic pain.
Dynorphin A activates bradykinin receptors to maintain neuropathic pain.
Nat Neurosci. 2006 Dec ;9(12):1534-40. Epub 2006 Nov 19 .

PubMed
MicroRNA modulation of RNA-binding protein regulatory elements.
MicroRNA modulation of RNA-binding protein regulatory elements.
RNA Biol. 2006 Apr ;3(2):57-9. Epub 2006 Apr 1 .

PubMed
Polyps: linear and volumetric measurement at CT colonography.
Polyps: linear and volumetric measurement at CT colonography.
Radiology. 2006 Dec ;241(3):802-11.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: