RNA Biol. 2006 Apr;3(2):57-9. Epub 2006 Apr 1.

MicroRNA modulation of RNA-binding protein regulatory elements.

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University at Albany-SUNY, Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Biomedical Sciences, School of Public Health, Rensselaer, New York 12144, USA.

Abstract

We propose that microRNAs could modulate RNA-binding protein binding sites in a dynamic manner. We suggest that the cis-regulatory code targeted by microRNAs is, at least in part, the same as that read by mRNA-binding proteins. Our hypothesis predicts that microRNAs indirectly or directly bind to RNA-binding protein binding sites. Alternatively, the microRNA-mRNA interactions can themselves be the target of an mRNA-binding protein. Lastly, we envision examples where multiple mRNA regulatory elements are simultaneously influenced by microRNA-mRNA interactions such that the binding of one or more microRNA results in conformational changes in the structure of the mRNA, thereby, either revealing or masking a second regulatory element.

PMID:: 17114943; [PubMed - indexed for MEDLINE]

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1R21HG003679/HG/NHGRI NIH HHS/United States

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