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Genes Dev. 2006 Nov 15;20(22):3084-8.

MtHAP2-1 is a key transcriptional regulator of symbiotic nodule development regulated by microRNA169 in Medicago truncatula.

Author information

  • 1LIPM (Laboratoire des Interactions Plantes-Microorganismes) INRA-CNRS (Institut de National de la Recherche-Centre national de la recherche scientifique), 31326 Castanet-Tolosan, France.

Abstract

In the model legume Medicago truncatula, we identified a new transcription factor of the CCAAT-binding family, MtHAP2-1, for which RNA interference (RNAi) and in situ hybridization experiments indicate a key role during nodule development, possibly by controlling nodule meristem function. We could also show that MtHAP2-1 is regulated by microRNA169, whose overexpression leads to the same nodule developmental block as MtHAP2-1 RNAi constructs. The complementary expression pattern of miR169 and MtHAP2-1 and the phenotype of miR169-resistant MtHAP2-1 nodules strongly suggest, in addition, that the miR169-mediated restriction of MtHAP2-1 expression to the nodule meristematic zone is essential for the differentiation of nodule cells.

PMID:
17114582
[PubMed - indexed for MEDLINE]
PMCID:
PMC1635144
Free PMC Article

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