Your browser version may not work well with NCBI's Web applications. More information here...
1: Expert Rev Mol Med. 2006 Nov 20;8(27):1-12.Click here to read Links

Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies.

Vasseur F, Meyre D, Froguel P.

Biostatistics Department Medical School and Public Health Clinics, University Hospital, Lille, France.

Adiponectin, a protein exclusively secreted by adipose tissue but present at low levels in obesity, is now widely recognised as a key determinant of insulin sensitivity and of protection against obesity-associated metabolic syndrome. In this review we explain how genetic findings have contributed to a better understanding of the physiological role of adiponectin in humans. The adiponectin-encoding gene, ADIPOQ (ACDC), is very polymorphic: many frequent exonic synonymous, intronic and promoter single-nucleotide polymorphisms (SNPs) have been identified, as well as a few rare exonic amino acid substitutions. Several of these variations additively contribute to the modulation of adiponectin level and function, and associate with insulin sensitivity, type 2 diabetes and vascular complications of obesity.

PMID: 17112391 [PubMed - indexed for MEDLINE]