Methods Enzymol. 2006;414:601-19.

Systems cell biology based on high-content screening.

Giuliano KA, Johnston PA, Gough A, Taylor DL.

Source

Cellumen Inc., Pittsburgh, PA, USA.

Abstract

A new discipline of biology has emerged since 2004, which we call "systems cell biology" (SCB). Systems cell biology is the study of the living cell, the basic unit of life, an integrated and interacting network of genes, proteins, and myriad metabolic reactions that give rise to function. SCB takes advantage of high-content screening platforms, but delivers more detailed profiles of cellular systemic function, including the application of advanced reagents and informatics tools to sophisticated cellular models. Therefore, an SCB profile is a cellular systemic response as measured by a panel of reagents that quantify a specific set of biomarkers.

PMID:: 17110213; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Biological Markers

Supplemental Content

Save items

Related citations in PubMed

Review Computational systems biology in drug discovery and development: methods and applications. [Drug Discov Today. 2007]
Review Computational systems biology in drug discovery and development: methods and applications.
Materi W, Wishart DS. Drug Discov Today. 2007 Apr; 12(7-8):295-303. Epub 2007 Mar 7.
Review Toward computational systems biology. [Cell Biochem Biophys. 2004]
Review Toward computational systems biology.
You L. Cell Biochem Biophys. 2004; 40(2):167-84.
Systems cell biology knowledge created from high content screening. [Assay Drug Dev Technol. 2005]
Systems cell biology knowledge created from high content screening.
Giuliano KA, Cheung WS, Curran DP, Day BW, Kassick AJ, Lazo JS, Nelson SG, Shin Y, Taylor DL. Assay Drug Dev Technol. 2005 Oct; 3(5):501-14.
Systems chemical biology. [Nat Chem Biol. 2007]
Systems chemical biology.
Oprea TI, Tropsha A, Faulon JL, Rintoul MD. Nat Chem Biol. 2007 Aug; 3(8):447-50.
Review Systems biology in drug discovery. [Nat Biotechnol. 2004]
Review Systems biology in drug discovery.
Butcher EC, Berg EL, Kunkel EJ. Nat Biotechnol. 2004 Oct; 22(10):1253-9.

See reviews... See all...

Cited by 8 PubMed Central articles

Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics. [Sensors (Basel). 2009]
Translocation Biosensors - Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics.
Fetz V, Knauer SK, Bier C, von Kries JP, Stauber RH. Sensors (Basel). 2009; 9(7):5423-45. Epub 2009 Jul 9.
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. [PLoS One. 2010]
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.
Gosai SJ, Kwak JH, Luke CJ, Long OS, King DE, Kovatch KJ, Johnston PA, Shun TY, Lazo JS, Perlmutter DH, et al. PLoS One. 2010 Nov 12; 5(11):e15460. Epub 2010 Nov 12.
Endocrine profiling and prioritization of environmental chemicals using ToxCast data. [Environ Health Perspect. 2010]
Endocrine profiling and prioritization of environmental chemicals using ToxCast data.
Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RJ. Environ Health Perspect. 2010 Dec; 118(12):1714-20. Epub 2010 Sep 8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Systems cell biology based on high-content screening.
Systems cell biology based on high-content screening.
Methods Enzymol. 2006 ;414:601-19.

PubMed
Development and application of automatic high-resolution light microscopy for ce...
Development and application of automatic high-resolution light microscopy for cell-based screens.
Methods Enzymol. 2006 ;414:228-47.

PubMed
The link between abdominal obesity, metabolic syndrome and cardiovascular diseas...
The link between abdominal obesity, metabolic syndrome and cardiovascular disease.
Nutr Metab Cardiovasc Dis. 2007 May ;17(4):319-26. Epub 2006 Nov 15 .

PubMed
Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cel...
Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells.
J Surg Res. 2007 Mar ;138(1):37-44. Epub 2006 Nov 15 .

PubMed
Progesterone receptors activation after acute cocaine administration.
Progesterone receptors activation after acute cocaine administration.
Brain Res. 2006 Dec 18 ;1126(1):188-92. Epub 2006 Nov 15 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Systems cell biology based on high-content screening.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information