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Genome Biol. 2006;7(11):R110.

ProCAT: a data analysis approach for protein microarrays.

Author information

  • 1Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.

Abstract

Protein microarrays provide a versatile method for the analysis of many protein biochemical activities. Existing DNA microarray analytical methods do not translate to protein microarrays due to differences between the technologies. Here we report a new approach, ProCAT, which corrects for background bias and spatial artifacts, identifies significant signals, filters nonspecific spots, and normalizes the resulting signal to protein abundance. ProCAT provides a powerful and flexible new approach for analyzing many types of protein microarrays.

PMID:
17109749
[PubMed - indexed for MEDLINE]
PMCID:
PMC1794587
Free PMC Article

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