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1: Genome Biol. 2006;7(11):R110.Click here to read Click here to read Links

ProCAT: a data analysis approach for protein microarrays.

Zhu X, Gerstein M, Snyder M.

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.

Protein microarrays provide a versatile method for the analysis of many protein biochemical activities. Existing DNA microarray analytical methods do not translate to protein microarrays due to differences between the technologies. Here we report a new approach, ProCAT, which corrects for background bias and spatial artifacts, identifies significant signals, filters nonspecific spots, and normalizes the resulting signal to protein abundance. ProCAT provides a powerful and flexible new approach for analyzing many types of protein microarrays.

PMID: 17109749 [PubMed - indexed for MEDLINE]

PMCID: PMC1794587