Fundam Clin Pharmacol. 2006 Dec;20(6):525-38.

Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids.

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Departments of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA. aleaf@partners.org

Abstract

There were already several epidemiologic studies that showed eating fish frequently seemed to reduce deaths from coronary heart disease. There were also observational and clinical trials, which more specifically showed that the reduction in cardiovascular deaths from eating fish were largely the result of n-3 polyunsaturated fatty acids in fish oil for the prevention of sudden cardiac death (SCD). This led me to perform a clinical trial in which all subjects had an implanted cardioverter-defibrillator and were at very high risk of SCD. The results of this study and the mechanisms by which the n-3 fish oil fatty acids prevent fatal cardiac arrhythmias will be the subject of this review.

PMID:: 17109646; [PubMed - indexed for MEDLINE]

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Review Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. [J Cardiovasc Med (Hagerstown)....]
Review Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids.
Leaf A. J Cardiovasc Med (Hagerstown). 2007 Sep; 8 Suppl 1:S27-9.
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Cited by 3 PubMed Central articles

High-throughput analysis of total plasma fatty acid composition with direct in situ transesterification. [PLoS One. 2010]
High-throughput analysis of total plasma fatty acid composition with direct in situ transesterification.
Glaser C, Demmelmair H, Koletzko B. PLoS One. 2010 Aug 9; 5(8):e12045. Epub 2010 Aug 9.
Docosahexaenoic acid has influence on action potentials and transient outward potassium currents of ventricular myocytes. [Lipids Health Dis. 2010]
Docosahexaenoic acid has influence on action potentials and transient outward potassium currents of ventricular myocytes.
Wang RX, Li XR, Guo T, Sun LP, Guo SX, Yang ZY, Yang XJ, Jiang WP. Lipids Health Dis. 2010 Apr 17; 9:39. Epub 2010 Apr 17.
Review Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis. [CMAJ. 2008]
Review Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis.
Jenkins DJ, Josse AR, Beyene J, Dorian P, Burr ML, LaBelle R, Kendall CW, Cunnane SC. CMAJ. 2008 Jan 15; 178(2):157-64.

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