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    Fitoterapia. 2007 Jan;78(1):7-11. Epub 2006 Sep 23.

    Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin.

    Source

    Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan. tsaiyc@ym.edu.tw

    Abstract

    Steam distilled essential oil from the aerial parts of Pogostemon cablin was analyzed by gas chromatography-mass spectrometry (GC-MS). Forty one compounds were identified of which alpha-guaiene (20.62%) and alpha-bulnesene (16.18%) were major constituents. Furthermore, fractionation of the essential oil from P. cablin guided by inhibitory activity against PAF-induced platelet aggregation led to the isolation of the sesquiterpene, alpha-bulnesene.

    PMID:
    17107759
    [PubMed - indexed for MEDLINE]

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