Abstract
Direct selection for 12 mutations (blm) conferring hypersensitivities to lethal effects of bleomycins in Saccharomyces cerevisiae resulted in mutants exhibiting cross-hypersensitivity to ionizing radiation and hydrogen peroxide. Remaining mutations did not confer cross-hypersensitivity to radiation. All blm mutations were recessive, except codominant blm3-1, and were assigned to seven complementation groups.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bleomycin / pharmacology*
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Cell Survival / drug effects
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Chromosome Mapping
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DNA / drug effects
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DNA / radiation effects
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Dose-Response Relationship, Drug
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Drug Resistance, Microbial / genetics
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Genetic Complementation Test
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Hydrogen Peroxide / pharmacology
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Radiation Tolerance
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Radiation, Ionizing
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Saccharomyces cerevisiae / genetics*
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Ultraviolet Rays / adverse effects
Substances
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Bleomycin
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DNA
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Hydrogen Peroxide