Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model

J Bacteriol. 1991 Jun;173(11):3605-8. doi: 10.1128/jb.173.11.3605-3608.1991.

Abstract

Direct selection for 12 mutations (blm) conferring hypersensitivities to lethal effects of bleomycins in Saccharomyces cerevisiae resulted in mutants exhibiting cross-hypersensitivity to ionizing radiation and hydrogen peroxide. Remaining mutations did not confer cross-hypersensitivity to radiation. All blm mutations were recessive, except codominant blm3-1, and were assigned to seven complementation groups.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bleomycin / pharmacology*
  • Cell Survival / drug effects
  • Chromosome Mapping
  • DNA / drug effects
  • DNA / radiation effects
  • Dose-Response Relationship, Drug
  • Drug Resistance, Microbial / genetics
  • Genetic Complementation Test
  • Hydrogen Peroxide / pharmacology
  • Radiation Tolerance
  • Radiation, Ionizing
  • Saccharomyces cerevisiae / genetics*
  • Ultraviolet Rays / adverse effects

Substances

  • Bleomycin
  • DNA
  • Hydrogen Peroxide