Fluoxetine monotherapy in attention-deficit/hypera...[Child Psychiatry Hum Dev. 2007]

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1: Child Psychiatry Hum Dev. 2007 Feb;37(3):241-53. Links

Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents.

Quintana H, Butterbaugh GJ, Purnell W, Layman AK.

Department of Psychiatry, Louisiana State University Health Sciences Center School of Medicine at New Orleans, 1542 Tulane Avenue, New Orleans, LA 70112, USA. hquint@lsuhsc.edu

Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing comorbid non-bipolar mood disorders. Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown. Therefore, we evaluated 30 children who met DSM-IV criteria for ADHD and comorbid non-bipolar mood disorders in a prospective, 6-12-week open-label, study of fluoxetine monotherapy. Fluoxetine was associated with significant decreases in the severity of depressive symptoms, and also, associated with significant decreases on subscales of inattention/overactivity and aggression/defiant symptoms-47% of participants were much or very much improved without observed adverse effects.

PMID: 17103304 [PubMed - indexed for MEDLINE]

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Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms. [J Am Acad Child Adolesc Psychiatry. 2005]
Comorbid oppositional defiant disorder and the risk of relapse during 9 months of atomoxetine treatment for attention-deficit/hyperactivity disorder. [Eur Child Adolesc Psychiatry. 2006]
Modafinil in children and adolescents with attention-deficit/hyperactivity disorder: a preliminary 8-week, open-label study. [Curr Med Res Opin. 2006]
Psychiatric comorbidity in Korean children and adolescents with attention-deficit hyperactivity disorder: psychopathology according to subtype. [Yonsei Med J. 2006]
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Fluoxetine (Prozac®, Prozac® Weekly, Sarafem®, ...) Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sud...

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Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents.

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