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Arch Neurol. 2006 Nov;63(11):1602-4.

Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease.

Author information

  • 1Istituto di Recovero e Cura a Carattere Scientifico San Giovanni di Dio Fatebenefratelli, University of Brescia, Brescia, Italy.

Abstract

OBJECTIVE:

To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD).

DESIGN:

Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks.

SETTING:

San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming.

MAIN OUTCOME MEASURES:

Language ability was assessed by accuracy of verbal response during online rTMS.

RESULTS:

Stimulation to the left and right DLPFC improved accuracy in action naming.

CONCLUSIONS:

These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.

PMID:
17101829
[PubMed - indexed for MEDLINE]
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