Source
Department of Child Health and Pediatrics, Moi University School of Medicine, PO Box 2582-30100, Eldoret, Kenya. nyandikom@yahoo.com
Abstract
OBJECTIVES:
Determine outcome differences between orphaned and non-orphaned children receiving antiretroviral therapy (ART).
DESIGN:
Retrospective review of prospectively recorded electronic data.
SETTING:
Nine HIV clinics in western Kenya.
POPULATION:
279 children on ART enrolled between August 2002 and February 2005.
MAIN MEASURES:
Orphan status, CD4%, sex- and age-adjusted height (HAZ) and weight (WAZ) z scores, ART adherence, mortality.
RESULTS:
Median follow-up was 34 months. Cohort included 51% males and 54% orphans. At ART initiation (baseline), 71% of children had CDC clinical stage B or C disease. Median CD4% was 9% and increased dramatically the first 30 weeks of therapy, then leveled off. Parents and guardians reported perfect adherence at every visit for 75% of children. Adherence and orphan status were not significantly associated with CD4% response. Adjusted for baseline age, follow-up was significantly shorter among orphaned children (median 33 vs. 41 weeks, P = 0.096). One-year mortality was 7.1% for orphaned and 6.6% for non-orphaned children (P = 0.836). HAZ and WAZ were significantly below norm in both groups. With ART, HAZ remained stable, while WAZ tended to increase toward the norm, especially among non-orphans. Orphans showed identical weight gains as non-orphans the first 70 weeks after start of ART but experienced reductions afterwards.
CONCLUSIONS:
Good ART adherence is possible in western rural Kenya. ART for HIV-infected children produced substantial and sustainable CD4% improvement. Orphan status was not associated with worse short-term outcomes but may be a factor for long-term therapy response. ART alone may not be sufficient to reverse significant developmental lags in the HIV-positive pediatric population.