Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bioresour Technol. 2007 Sep;98(12):2313-20. Epub 2006 Nov 9.

The production of polyhydroxyalkanoates in recombinant Escherichia coli.

Author information

  • 1State Key Lab of Microbial Technology, Life Science School, Shandong University, 250100 Jinan, PR China.

Abstract

Polyhydroxyalkanoates, the natural polyester that many microorganisms accumulate to store carbon and reducing equivalents, have been considered as a future alternative of traditional plastic due to their special properties. In Escherichia coli, a previous non-polyhydroxyalkanoates producer, pathway engineering has been developed as a very powerful approach to set up microbial production process through the introduction of direct genetic changes by recombinant DNA technology. Various metabolic pathways leading to the polyhydroxyalkanoates accumulation with desirable properties at low-cost and high-productivity have been developed. At the same time, high density fermentation technology of E. coli provides an efficient polyhydroxyalkanoates production strategy. This review focused on metabolic engineering, fermentation and downstream process aiming to polyhydroxyalkanoates production in E. coli.

PMID:
17097289
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk