Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2006 Dec;16(6):693-700. Epub 2006 Nov 9.

Item, context and relational episodic encoding in humans.

Author information

  • 1Department of Psychology, Center for Neural Science, 6 Washington Place, Meyer Building, Room 866B, New York University, New York, NY 10003, USA. lila.davachi@nyu.edu

Abstract

Recent functional imaging work supports the view that item and relational memory depend upon distinct encoding operations within the medial temporal lobe. Specifically, emerging findings demonstrate that the level of engagement of perirhinal cortex predicts later memory for individual items, whereas the level of hippocampal processing correlates with later relational memory, or recovery of additional episodic details. Furthermore, recent functional magnetic resonance imaging evidence in humans suggests that medial temporal lobe cortical input structures, the perirhinal and posterior parahippocampal cortices, differentially participate in the encoding of objects and their context, providing domain-specific input to the hippocampus. Taken together, these data help to construct a working model of how distinct medial temporal lobe structures participate in episodic memory formation with domain-general relational binding mechanisms supported by the hippocampus and provide emerging evidence for domain-specificity within the perirhinal and parahippocampal cortices.

PMID:
17097284
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk