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Int J Geriatr Psychiatry. 2007 Jun;22(6):536-42.

Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly.

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  • 1Department of Psychiatry, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA. wqiu@tufts-nemc.org

Abstract

BACKGROUND:

Depression often precedes the onset of Alzheimer's disease (AD) before the appearance of cognitive symptoms. Plasma Amyloid-beta peptide 42 (Abeta42) declines before and soon after the onset of AD, yet the relationship between plasma Abeta42 and depression is unclear.

METHODS:

We used 515 homebound elders aged 60 and older in a population-based, cross-sectional study to investigate associations between plasma Abeta levels and depression with and without cardiovascular co-morbidities. Depression was evaluated by using the Center for Epidemiological Studies Depression (CES-D) scale. Plasma Abeta40 and Abeta42 were measured.

RESULTS:

The elderly with depression had lower plasma Abeta42 (median: 15.3 vs. 18.9, p = 0.008) than those without depression. The CES-D score was inversely associated with plasma Abeta42 (p = 0.001) in subjects with no cardiovascular disease (CVD); however, in the presence of CVD, this association did not exist. Low plasma Abeta42 (OR = 0.41, p = 0.007) and the presence of CVD (OR = 1.84, p = 0.005) were independently associated with depression after adjusting for the confounders of age, stroke and apolipoprotein E4.

CONCLUSIONS:

Depressive symptoms are associated with low plasma Abeta42 independently of CVD. Prospective studies are needed to determine whether depression associated with low plasma Abeta42 is a separate depression subtype that could predict the onset of AD.

Copyright 2006 John Wiley & Sons, Ltd.

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PMID:
17096467
[PubMed - indexed for MEDLINE]
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