A complex oscillating network of signaling genes u...[Science. 2006]

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1: Science. 2006 Dec 8;314(5805):1595-8. Epub 2006 Nov 9. Links

Comment in:: Science. 2007 Feb 23;315(5815):1077.

A complex oscillating network of signaling genes underlies the mouse segmentation clock.

Dequéant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquié O.

Howard Hughes Medical Institute, Kansas City, MO 64110, USA.

The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch-fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

PMID: 17095659 [PubMed - indexed for MEDLINE]

Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways.
J Theor Biol. 2008 Jun 7; 252(3):574-85. Epub 2008 Jan 18.

[J Theor Biol. 2008]
ReviewThe vertebrate segmentation clock and its role in skeletal birth defects.
Birth Defects Res C Embryo Today. 2007 Jun; 81(2):121-33.

[Birth Defects Res C Embryo Today. 2007]
Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Dev Biol. 2009 Jun 1; 330(1):21-31. Epub 2009 Mar 6.

[Dev Biol. 2009]
Wnt3a plays a major role in the segmentation clock controlling somitogenesis.
Dev Cell. 2003 Mar; 4(3):395-406.

[Dev Cell. 2003]
ReviewThe long and short of it: somite formation in mice.
Dev Dyn. 2006 Sep; 235(9):2330-6.

[Dev Dyn. 2006]
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[PLoS One. 2009]
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Cited by 18 PubMed Central articles

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