Trends Neurosci. 1991 Mar;14(3):96-100.

Direct regulation of ion channels by fatty acids.

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Dept of Physiology, University of Massachusetts Medical School, Worcester 01655.

Abstract

A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transduction pathways that require soluble factors such as nucleotides and calcium. Thus, fatty acids themselves appear to regulate the action of channels directly, much as they regulate the action of several purified enzymes, and might constitute a new class of first or second messengers acting on ion channels.

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Trends Neurosci. 1991 Sep;14(9):405.

PMID:: 1709540; [PubMed - indexed for MEDLINE]

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DK 31620/DK/NIDDK NIH HHS/United States

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