Nat Rev Cancer. 2006 Dec;6(12):967-74. Epub 2006 Nov 9.

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

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Division of Cell & Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK. inke@lifesci.dundee.ac.uk

Abstract

Mutation of APC (adenomatous polyposis coli) is a common factor in most colorectal cancers. APC has many functions, the most prominent is its capacity to regulate beta-catenin-mediated gene transcription in response to Wnt signalling. Loss of APC leads to deregulated beta-catenin and this is intimately linked with tumour formation. However, recent evidence indicates that the interaction of APC with the cytoskeleton might also contribute to tumour initiation and progression. How does APC interact with the cytoskeleton and how could this play a part in colorectal tumorigenesis?

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