Curr Rheumatol Rep. 2006 Dec;8(6):474-9.

Osteogenesis imperfecta: new treatment options.

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Department of Pediatrics, Edouard Herrriot Hospital, 5, place d'Arsonval, 69437 Lyon Cedex 03, France.

Abstract

Classic treatments of osteogenesis imperfecta for children and adults include rehabilitation therapy and orthopedic surgery. New treatments include bisphosphonates. Among them, the effects of intravenous pamidronate have been primarily evaluated in children in several open cohorts. Treatments of adult patients are not established. Several other treatments may have an effect on the fracture rate. However, further studies are needed to demonstrate an effect on fracture rate in children and adult patients. A new approach has been developed to replace mutated genes using mesenchymal stem cells and a construct, which inactivates COL1A1.

PMID:: 17092446; [PubMed - indexed for MEDLINE]

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