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Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis.
New York University School of Medicine, New York, New York 10016, USA. jachkar@aecom.yu.edu
The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from approximately 80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.
PMID: 17090645 [PubMed - indexed for MEDLINE]
PMCID: PMC1656542
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Cited by 3 PubMed Central articles
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[BMC Infect Dis. 2007]