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IUBMB Life. 2006 Nov;58(11):621-31.

ERK1/2 MAP kinases in cell survival and apoptosis.

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  • 1Brain Tumor Center and Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030, USA. zhiminlu@mdanderson.org


ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.

[PubMed - indexed for MEDLINE]
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