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Curr Opin Neurobiol. 2006 Dec;16(6):638-44. Epub 2006 Nov 3.

Mechanisms for recovery of motor function following cortical damage.

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  • 1University of Kansas Medical Center, Landon Center on Aging, MS 1005 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.


Recent studies of focal injury to the cerebral cortex have demonstrated that the remaining, intact tissue undergoes structural and functional changes that could play a substantial role in neurological recovery. New information regarding the molecular and cellular environment in the adjacent, intact tissue has suggested that waves of growth promotion and inhibition modulate the self-repair processes of the brain. Furthermore, recent studies have documented widespread neurophysiological and neuroanatomical changes in regions remote from a focal cortical injury, suggesting that entire cortical networks participate in the recovery process.

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