Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr

Bioorg Med Chem. 2007 Jan 15;15(2):988-96. doi: 10.1016/j.bmc.2006.10.034. Epub 2006 Oct 19.

Abstract

Three new alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula used for treatment of rheumatoid arthritis in China and synthesis of one new immunosuppressive alkaloid was achieved. These compounds, including the crude extracts of this herb, exhibited strong activities in the inhibition of T and B cell proliferation.

MeSH terms

  • Animals
  • Annonaceae / chemistry*
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology
  • Cell Proliferation / drug effects
  • Cyclosporine / antagonists & inhibitors
  • Cyclosporine / pharmacology
  • Dimethyl Sulfoxide
  • Drug Design
  • Immunity, Cellular / drug effects
  • Immunosuppressive Agents / antagonists & inhibitors
  • Immunosuppressive Agents / chemical synthesis*
  • Immunosuppressive Agents / isolation & purification
  • Immunosuppressive Agents / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred BALB C
  • Plant Bark / chemistry
  • Plant Extracts / analysis
  • Plant Stems / chemistry
  • Solutions
  • Solvents
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Spleen / cytology
  • Spleen / drug effects
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology

Substances

  • Immunosuppressive Agents
  • Plant Extracts
  • Solutions
  • Solvents
  • Cyclosporine
  • Dimethyl Sulfoxide