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Clin Calcium. 2006 Nov;16(11):1812-6.

[Wnt signaling and glucocorticoid-induced osteoporosis].

[Article in Japanese]

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  • 1Kyushyu University, Graduate School of Medical Sciences, Department of Geriatric Medicine.


Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Analyses of the mutations in LDL receptor-related protein 5 (LRP5), a Wnt co-receptor, revealed that the Wnt signaling pathway is important for bone formation. Glucocorticoids suppress the canonical Wnt signaling pathway by such mechanisms as the enhancement the expression of dickkopf-1 (Dkk-1) and secreted frizzled-related protein 1 (sFRP1), and activation of the glycogen synthase kinase-3beta (GSK-3beta) activity. The inhibition of the canonical Wnt signal by glucocorticoid may be involved in the pathogenesis of glucocorticoid-induced osteoporosis.

[PubMed - indexed for MEDLINE]
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