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Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16942-7. Epub 2006 Oct 30.

Vaccine assembly from surface proteins of Staphylococcus aureus.

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  • 1Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.


Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, SdrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.

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