Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells

Sabine Gröbner; Sebastian Schulz; Irena Soldanova; Dani S J Gunst; Michaela Waibel; Sebastian Wesselborg; Stefan Borgmann; Ingo B Autenrieth

doi:10.1128/IAI.00756-06

Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells

Infect Immun. 2007 Jan;75(1):512-7. doi: 10.1128/IAI.00756-06. Epub 2006 Oct 30.

Authors

Sabine Gröbner¹, Sebastian Schulz, Irena Soldanova, Dani S J Gunst, Michaela Waibel, Sebastian Wesselborg, Stefan Borgmann, Ingo B Autenrieth

Affiliation

¹ Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tübingen, Elfriede-Aulhorn-Str. 6, D-72076 Tübingen, Germany. sabine.groebner@med.uni-tuebingen.de

Abstract

In an initial period (< or =4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis / physiology*
Bacterial Proteins / immunology*
Caspase 8 / metabolism
Dendritic Cells / microbiology*
Dendritic Cells / pathology
Enzyme Activation / immunology
Immunoblotting
Mice
Signal Transduction / immunology*
Toll-Like Receptor 4 / metabolism*
Yersinia Infections / immunology*
Yersinia enterocolitica / immunology

Substances

Bacterial Proteins
Toll-Like Receptor 4
YopP protein, Yersinia
Caspase 8