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Biochem Soc Trans. 2006 Dec;34(Pt 6):1079-81.

A new paradigm for the regulation of the mammalian ribosomal RNA genes.

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  • 1Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St. Patrick, 9 rue McMahon, QC, Canada G1R 3S3. Tom.Moss@crhdq.ulaval.ca

Abstract

Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.

PMID:
17073755
[PubMed - indexed for MEDLINE]
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