Send to:

Choose Destination
See comment in PubMed Commons below
Biochem Soc Trans. 2006 Dec;34(Pt 6):1079-81.

A new paradigm for the regulation of the mammalian ribosomal RNA genes.

Author information

  • 1Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St. Patrick, 9 rue McMahon, QC, Canada G1R 3S3.


Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk