Display Settings:


Send to:

Choose Destination
Biochem Soc Trans. 2006 Dec;34(Pt 6):1079-81.

A new paradigm for the regulation of the mammalian ribosomal RNA genes.

Author information

  • 1Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St. Patrick, 9 rue McMahon, QC, Canada G1R 3S3. Tom.Moss@crhdq.ulaval.ca


Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Portland Press
    Write to the Help Desk