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Mini Rev Med Chem. 2006 Oct;6(10):1075-80.

Intracellular amyloid beta-protein and its associated molecules in the pathogenesis of Alzheimer's disease.

Author information

  • 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ohyagi@neuro.med.kyushu-u.ac.jp

Abstract

Amyloid beta-protein (Abeta) plays a pivotal role in Alzheimer's disease (AD). Therapeutic strategies inhibiting Abeta aggregation and promoting extracellular Abeta removal are currently advocated. Here, we review recent literature on intracellular Abeta, especially intranuclear Abeta, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Abeta-related pathogenesis.

PMID:
17073707
[PubMed - indexed for MEDLINE]
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