Oncogene. 2006 Oct 30;25(51):6680-4.

Introduction to NF-kappaB: players, pathways, perspectives.

Source

Biology Department, Boston University, Boston, MA 02215, USA. gilmore@bu.edu

Abstract

This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-kappaB). It provides an overview of the discovery and current status of NF-kappaB as a research topic. Described are the structures, activities and regulation of the proteins in the NF-kappaB family of transcription factors. NF-kappaB signaling is primarily regulated by inhibitor kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappaB pathways. The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-kappaB.

PMID:: 17072321; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

NF-kappa B

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Review Transcriptional regulation via the NF-kappaB signaling module. [Oncogene. 2006]
Review Transcriptional regulation via the NF-kappaB signaling module.
Hoffmann A, Natoli G, Ghosh G. Oncogene. 2006 Oct 30; 25(51):6706-16.
Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells. [Cancer Sci. 2007]
Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells.
Ding J, Wu K, Zhang D, Luo W, Li J, Ouyang W, Song L, Huang C. Cancer Sci. 2007 Sep; 98(9):1323-9. Epub 2007 Jul 19.
Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle. [Biochem J. 2008]
Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle.
Hu W, Li F, Mahavadi S, Murthy KS. Biochem J. 2008 May 15; 412(1):35-43.
Review IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB. [Cytokine Growth Factor Rev. 2008]
Review IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.
Schmid JA, Birbach A. Cytokine Growth Factor Rev. 2008 Apr; 19(2):157-65. Epub 2008 Mar 4.
New insights into NF-kappaB regulation and function. [Trends Immunol. 2008]
New insights into NF-kappaB regulation and function.
Sun SC, Ley SC. Trends Immunol. 2008 Oct; 29(10):469-78. Epub 2008 Sep 3.

See reviews... See all...

Cited by 97 PubMed Central articles

M-CSF induces monocyte survival by activating NF-κB p65 phosphorylation at Ser276 via protein kinase C. [PLoS One. 2011]
M-CSF induces monocyte survival by activating NF-κB p65 phosphorylation at Ser276 via protein kinase C.
Wang Y, Mo X, Piper MG, Wang H, Parinandi NL, Guttridge D, Marsh CB. PLoS One. 2011; 6(12):e28081. Epub 2011 Dec 22.
The c-Rel Transcription Factor in Development and Disease. [Genes Cancer. 2011]
The c-Rel Transcription Factor in Development and Disease.
Gilmore TD, Gerondakis S. Genes Cancer. 2011 Jul; 2(7):695-711.
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. [Proc Natl Acad Sci U S A. 2012]
Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders.
Raskatov JA, Meier JL, Puckett JW, Yang F, Ramakrishnan P, Dervan PB. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1023-8. Epub 2011 Dec 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioAssay
PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Introduction to NF-kappaB: players, pathways, perspectives.
Introduction to NF-kappaB: players, pathways, perspectives.
Oncogene. 2006 Oct 30 ;25(51):6680-4.

PubMed
The International Association for the Study of Lung Cancer Staging Project: prog...
The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer.
J Thorac Oncol. 2009 Jul ;4(7):792-801.

PubMed
The natural history of cerebellar hemangioblastomas in von Hippel-Lindau disease...
The natural history of cerebellar hemangioblastomas in von Hippel-Lindau disease.
AJNR Am J Neuroradiol. 2003 Sep ;24(8):1570-4.

PubMed
[Hereditary haemochromatosis: novel genes, novel diseases and hepcidin].
[Hereditary haemochromatosis: novel genes, novel diseases and hepcidin].
Ned Tijdschr Geneeskd. 2007 May 19 ;151(20):1121-7.

PubMed
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cel...
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.
Nature. 2008 Jul 24 ;454(7203):528-32. Epub 2008 Jun 15 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: