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Nat Neurosci. 2006 Dec;9(12):1477-8. Epub 2006 Oct 29.

A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms.

Author information

  • 1Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK. jhall5@staffmail.ed.ac.uk

Abstract

NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.

PMID:
17072305
[PubMed - indexed for MEDLINE]
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