Math Med Biol. 2007 Mar;24(1):85-109. Epub 2006 Oct 27.

Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study.

Stevens SA, Previte M, Lakin WD, Thakore NJ, Penar PL, Hamschin B.

Source

School of Science, Penn State Erie, The Behrend College, Erie, PA 16563-0203, USA. sas56@psu.edu

Abstract

Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.

PMID:: 17071863; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, Non-P.H.S.

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