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    Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. Epub 2006 Oct 7.

    Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

    Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT.

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    Abbott, Dept. 47F, Bldg. AP-10, Rm. 301, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA.

    Abstract

    Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.

    PMID:
    17070044
    [PubMed - indexed for MEDLINE]

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