Influenza vaccine effectiveness among 50-64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003-2004

Vaccine. 2007 Jan 2;25(1):154-60. doi: 10.1016/j.vaccine.2006.05.129. Epub 2006 Aug 2.

Abstract

During the 2003-2004 influenza season, we conducted a case-control study of influenza vaccine effectiveness (VE) among Colorado residents aged 50-64 years. Cases (n=330) were identified from laboratory-confirmed influenza reports to the Colorado Department of Public Health and Environment (CDPHE). Controls (n=1055) were recruited by random-digit dial telephone survey. VE was 60% (43-72%) and 48% (21-66%) among those without and with high-risk medical conditions, respectively. VE was 90% (68-97%) and 36% (0-63%) against influenza-related hospitalization for persons without and with high-risk conditions, respectively.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigenic Variation*
  • Case-Control Studies
  • Colorado
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Influenza A Virus, H3N2 Subtype / classification*
  • Influenza A Virus, H3N2 Subtype / genetics
  • Influenza A Virus, H3N2 Subtype / immunology*
  • Influenza Vaccines / administration & dosage
  • Influenza Vaccines / immunology
  • Influenza Vaccines / therapeutic use*
  • Influenza, Human / epidemiology*
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control*
  • Influenza, Human / virology
  • Male
  • Middle Aged
  • Seasons
  • Species Specificity
  • Treatment Outcome
  • Vaccination / statistics & numerical data

Substances

  • Influenza Vaccines