Hyperdynamic circulation in cirrhosis: a role for ...[Lancet. 1991]

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1: Lancet. 1991 Mar 30;337(8744):776-8. Links

Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

Vallance P, Moncada S.

Wellcome Research Laboratories, Langley Court, Beckenham, Kent, UK.

Hypotension, low systemic vascular resistance, and a reduced sensitivity to vasoconstrictors are features of cirrhosis. These cardiovascular changes might be the result of increased synthesis of a vasodilator. Nitric oxide (NO), a potent vasodilator, is synthesised in and released from peripheral blood-vessels in man. Studies in animals indicate that bacterial endotoxin and cytokines induce NO synthase expression in vessel walls, with sustained NO release and consequent hypotension. Endotoxaemia is a common feature of cirrhosis; persistent induction of NO synthase may account for the associated haemodynamic changes.

PMID: 1706450 [PubMed - indexed for MEDLINE]

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ReviewThe role of nitric oxide in portal hypertensive systemic and portal vascular pathology. [Acta Gastroenterol Belg. 1997]
Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine. [J Natl Cancer Inst. 1992]
ReviewHemodynamic alterations in liver cirrhosis. [Mol Aspects Med. 2008]

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Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

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