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J Org Chem. 2006 Oct 27;71(22):8673-5.

Expedient five-step synthesis of SIB-1508Y from natural nicotine.

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  • 1Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.


Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.

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