J Negat Results Biomed. 2006 Oct 24;5:15.

Polymorphisms within inflammatory genes and colorectal cancer.

Landi S, Gemignani F, Bottari F, Gioia-Patricola L, Guino E, Cambray M, Biondo S, Capella G, Boldrini L, Canzian F, Moreno V.

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Genetics-Department of Biology, University of Pisa, via S, Giuseppe 22, 56126, Pisa, Italy. slandi@biologia.unipi.it

Abstract

BACKGROUND:

Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).

RESULTS:

There was no statistically significant association between the SNPs investigated and colorectal cancer risk.

CONCLUSION:

The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.

PMID:: 17062130; [PubMed - indexed for MEDLINE]
PMCID:: PMC1634873

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Inflammation Mediators

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