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AJR Am J Roentgenol. 2006 Nov;187(5):1235-9.

Fast 3D cine steady-state free precession imaging with sensitivity encoding for assessment of left ventricular function in a single breath-hold.

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  • 1Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Abstract

OBJECTIVE:

This study compares single breath-hold 3D cine steady-state free precession (SSFP) MRI using sensitivity encoding (SENSE) with standard 2D cine SSFP imaging in the quantitative evaluation of global left ventricular (LV) function.

MATERIALS AND METHODS:

The LV function of 22 healthy volunteers and 15 patients was evaluated using a standard 2D SSFP sequence and a 3D SSFP sequence with SENSE at 1.5 T. Ventricular volume, ejection fraction, and LV mass were calculated with each method, and signal-to-noise ratios (SNRs) and myocardium-to-blood contrast-to-noise ratios (CNRs) were measured. Agreement between the two methods was assessed using Bland-Altman analysis, and results were compared using a paired Student's t test (p < 0.05). The local institutional review board approved the study protocol, and all participants gave signed informed consent. The study complied with the Health Insurance Portability and Accountability Act.

RESULTS:

Both techniques produced similar estimates of ejection fraction (mean bias +/- SD, -1.2% +/- 3.6%) and LV mass (mean bias, +/- SD-1.2 +/- 10.9 g). No significant differences were found in calculated volumes, ejection fraction, or LV mass between the two methods. Acquisition time was reduced by 82%, to a single breath-hold (18 +/- 3 seconds), with the 3D SSFP technique. SNR and CNR were significantly lower with the 3D method than with the standard method.

CONCLUSION:

Three-dimensional SSFP imaging with SENSE can reduce acquisition time to a single breath-hold and can provide LV function quantification comparable to that obtained with conventional 2D SSFP imaging.

PMID:
17056910
[PubMed - indexed for MEDLINE]
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